Muscle glycome in idiopathic inflammatory myopathies: Impact in IL-6 production and disease prognosis.

ABSTRACT: Idiopathic inflammatory myopathies (IIM) are a group of chronic autoimmune diseases mainly affecting proximal muscles. Absence of meaningful prognostic factors in IIM has hindered new therapies development. Glycans are essential molecules that regulate immunological tolerance and consequently the onset of autoreactive immune response. We showed that muscle biopsies from patients with IIM revealed a deficiency in the glycosylation pathway resulting in loss of branched N-glycans. At diagnosis, this glycosignature predicted disease relapse and treatment refractoriness. Peripheral CD4⁺ T cells from active-disease patients shown a deficiency in branched N-glycans, linked to increased IL-6 production. Glycan supplementation, restoring homeostatic glycosylation profile, l

SUBMITTER: Campar A 

PROVIDER: S-EPMC10316658 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature