Derivation and External Validation of a Clinical Prediction Model for Viral Diarrhea Etiology in Bangladesh.

ABSTRACT:

Background

Antibiotics are commonly overused for diarrheal illness in many low- and middle-income countries, partly due to a lack of diagnostics to identify viral cases, in which antibiotics are not beneficial. This study aimed to develop clinical prediction models to predict risk of viral-only diarrhea across all ages, using routinely collected demographic and clinical variables.

Methods

We used a derivation dataset from 10 hospitals across Bangladesh and a separate validation dataset from the icddr,b Dhaka Hospital. The primary outcome was viral-only etiology determined by stool quantitative polymerase chain reaction. Multivariable logistic regression models were fit and externally validated; discrimination was quantified using area under the receiver operating characteris

SUBMITTER: Garbern SC 

PROVIDER: S-EPMC10316693 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature