Biological stability of DNA methylation measurements over varying intervals of time and in the presence of acute stress.

ABSTRACT: Identifying factors that influence the stability of DNA methylation measurements across biological replicates is of critical importance in basic and clinical research. Using a within-person between-group experimental design (n = 31, number of observations = 192), we report the stability of biological replicates over a variety of unique temporal scenarios, both in the absence and presence of acute psychosocial stress, and between individuals who have experienced early life adversity (ELA) and non-exposed individuals. We found that varying time intervals, acute stress, and ELA exposure influenced the stability of repeated DNA methylation measurements. In the absence of acute stress, probes were less stable as time passed; however, stress exerted a stabilizing influence on probes over

SUBMITTER: Apsley AT 

PROVIDER: S-EPMC10316737 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature