Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.

ABSTRACT: Neurofilament light chain, a putative measure of neuronal damage, is measurable in blood and CSF and is predictive of cognitive function in individuals with Alzheimer's disease. There has been limited prior work linking neurofilament light and functional connectivity, and no prior work has investigated neurofilament light associations with functional connectivity in autosomal dominant Alzheimer's disease. Here, we assessed relationships between blood neurofilament light, cognition, and functional connectivity in a cross-sectional sample of 106 autosomal dominant Alzheimer's disease mutation carriers and 76 non-carriers. We employed an innovative network-level enrichment analysis approach to assess connectome-wide associations with neurofilament light. Neurofilament light was positively cor

SUBMITTER: Wheelock MD 

PROVIDER: S-EPMC10316768 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature