Altered nucleus accumbens functional connectivity precedes apathy in Parkinson's disease.

ABSTRACT: Work in animal and human neuroscience has identified neural regions forming a network involved in the production of motivated, goal-directed behaviour. In particular, the nucleus accumbens and anterior cingulate cortex are recognized as key network nodes underlying decisions of whether to exert effort for reward, to drive behaviour. Previous work has convincingly shown that this cognitive mechanism, known as effort-based decision making, is altered in people with Parkinson's disease with a syndrome of reduced goal-directed behaviour-apathy. Building on this work, we investigated whether the neural regions implementing effort-based decision-making were associated with apathy in Parkinson's disease, and more importantly, whether changes to these regions were evident prior to apathy developme

SUBMITTER: Morris LA 

PROVIDER: S-EPMC10316779 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature