Association between Matrix Metallopeptidase 9 Polymorphism and Breast Cancer Risk.

ABSTRACT:

Objective

 Epidemiological studies have shown evidence of the effect of genetic variations in the pathogenesis of breast cancer and have suggested a relationship of the disease with genetic polymorphisms. Matrix metallopeptidase 9 (MMP-9) is a collagenase responsible for the degradation of type IV collagen, the major component of the basement membrane, and other essential extra cellular matrix components, being involved in the tumor cell invasion and metastasis. Our objective was to evaluate the relationship between the MMP-9-1562 C/T polymorphism (rs 3918242) and the risk of developing breast cancer.

Methods

 In this case-control study, the frequency of the MMP-9-1562 C/T polymorphism (rs 3918242) was determined in 148 women with breast cancer and 245 women wi

SUBMITTER: Felizi RT 

PROVIDER: S-EPMC10316932 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature