Specific resistance prevents the evolution of general resistance and facilitates disease emergence.

ABSTRACT: Host-shifts, where pathogens jump from an ancestral host to a novel host, can be facilitated or impeded by standing variation in disease resistance, but only if resistance provides broad-spectrum general resistance against multiple pathogen species. Host resistance comes in many forms and includes both general resistance, as well as specific resistance, which may only be effective against a single pathogen species or even genotype. However, most evolutionary models consider only one of these forms of resistance, and we have less understanding of how these two forms of resistance evolve in tandem. Here, we develop a model that allows for the joint evolution of specific and general resistance and asks if the evolution of specific resistance drives a decrease in the evolution of general resis

SUBMITTER: Hulse SV 

PROVIDER: S-EPMC10316961 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature