ADAR1 Non-Editing Function in Macrophage Activation and Abdominal Aortic Aneurysm.

ABSTRACT:

Background

Macrophage activation plays a critical role in abdominal aortic aneurysm (AAA) development. However, molecular mechanisms controlling macrophage activation and vascular inflammation in AAA remain largely unknown. The objective of the study was to identify novel mechanisms underlying adenosine deaminase acting on RNA (ADAR1) function in macrophage activation and AAA formation.

Methods

Aortic transplantation was conducted to determine the importance of nonvascular ADAR1 in AAA development/dissection. Ang II (Angiotensin II) infusion of ApoE-/- mouse model combined with macrophage-specific knockout of ADAR1 was used to study ADAR1 macrophage-specific role in AAA formation/dissection. The relevance of macrophage ADAR1 to human AAA was examined using human aneurysm spe

SUBMITTER: Cai D 

PROVIDER: S-EPMC10316962 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature