A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic ductal adenocarcinoma.

ABSTRACT: In humans, the natural killer (NK) cell marker CD161 identifies several subsets of T cells, including a polyclonal CD8 αβ T cell receptor-expressing subset with characteristic specificity for tissue-localized viruses. This subset also displays enhanced cytotoxic and memory phenotypes. Here, we characterized this unique T cell subset and determined its potential suitability for use in chimeric antigen receptor (CAR) T cell therapy. In mice, gene expression profiling among the CD161-equivalent CD8⁺ T cell populations (CD8⁺NK1.1⁺) revealed substantial up-regulation of granzymes, perforin, killer lectin-like receptors, and innate signaling molecules in comparison to CD8⁺NK1.1^- T cells. Adoptive transfer of CD8⁺NK1.1⁺

SUBMITTER: Konduri V 

PROVIDER: S-EPMC10316998 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature