Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population.

ABSTRACT:

Objective

To investigate the relationship between single nucleotide polymorphisms (SNPs) related to vitamin D (VitD) metabolism and post-stroke depression (PSD) in patients with ischemic stroke.

Methods

A total of 210 patients with ischemic stroke were enrolled at the Department of Neurology in Xiangya Hospital, Central South University, from July 2019 to August 2021. SNPs in the VitD metabolic pathway (VDR, CYP2R1, CYP24A1, and CYP27B1) were genotyped using the SNPscan^™ multiplex SNP typing kit. Demographic and clinical data were collected using a standardized questionnaire. Multiple genetic models including dominant, recessive, and over-dominant models were utilized to analyze the associations between SNPs and PSD.

Results

In t

SUBMITTER: Sun D 

PROVIDER: S-EPMC10317012 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature