MiR-455-3p ameliorates pancreatic acinar cell injury by targeting Slc2a1.

ABSTRACT:

Objective

With the number of patients with acute pancreatitis (AP) increasing year by year, it is pressing to explore new key genes and markers for the treatment of AP. miR-455-3p/solute carrier family 2 member 1 (Slc2a1) obtained through bioinformatics analysis may participate in the progression of AP.

Materials and methods

The C57BL/6 mouse model of AP was constructed for subsequent studies. Through bioinformatics analysis, the differentially expressed genes related to AP were screened and hub genes were identified. A caerulein-induced AP animal model was constructed to detect the pathological changes of mouse pancreas by HE staining. The concentrations of amylase and lipase were measured. Primary mouse pancreatic acinar cells were isolated and subjected to microscopy to o

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC10317017 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature