Alignment and photooxidation dynamics of a perylene diimide chromophore in lipid bilayers.

ABSTRACT: We present a method of enabling photochemical reactions in water by using biomimetic, water-soluble liposomes and a specifically functionalized perylene diimide chromophore. Linking two flexible saturated C4-alkyl chains with terminal positively charged trimethylammonium groups to the rigid perylene diimide core yielded [1]²⁺ allowing for its co-assembly at the lipid bilayer interface of DOPG liposomes (DOPG = 1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)) with a preferred orientation and in close proximity to the water interface. According to molecular dynamics simulations the chromophore aligns preferably parallel to the membrane surface which is supported by confocal microscopy. Irradiation experiments with visible light and in the pre

SUBMITTER: Sinambela N 

PROVIDER: S-EPMC10317050 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature