Highly complete long-read genomes reveal pangenomic variation underlying yeast phenotypic diversity.

ABSTRACT: Understanding the genetic causes of trait variation is a primary goal of genetic research. One way that individuals can vary genetically is through variable pangenomic genes: genes that are only present in some individuals in a population. The presence or absence of entire genes could have large effects on trait variation. However, variable pangenomic genes can be missed in standard genotyping workflows, owing to reliance on aligning short-read sequencing to reference genomes. A popular method for studying the genetic basis of trait variation is linkage mapping, which identifies quantitative trait loci (QTLs), regions of the genome that harbor causative genetic variants. Large-scale linkage mapping in the budding yeast Saccharomyces cerevisiae has found thousands of QTLs affecting m

SUBMITTER: Weller CA 

PROVIDER: S-EPMC10317115 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature