Mammalian cargo receptors for endoplasmic reticulum-to-Golgi transport: mechanisms and interactions.

ABSTRACT: Proteins that are destined to enter the secretory pathway are synthesized on the rough endoplasmic reticulum (ER) and then translocated into the ER lumen, where they undergo posttranslational modifications, folding, and assembly. After passing a quality control system, the cargo proteins are packaged into coat protein complex II (COPII) vesicles to exit the ER. In metazoans, most COPII subunits have multiple paralogs, enabling COPII vesicles the flexibility to transport a diverse range of cargo. The cytoplasmic domains of transmembrane proteins can interact with SEC24 subunits of COPII to enter the ER exit sites. Some transmembrane proteins may also act as cargo receptors that bind soluble secretory proteins within the ER lumen, enabling them to enter COPII vesicles. The cytoplasmic domain

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10317151 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature