Microfluidic platform using focused ultrasound passing through hydrophobic meshes with jump availability.

ABSTRACT: Applications in chemistry, biology, medicine, and engineering require the large-scale manipulation of a wide range of chemicals, samples, and specimens. To achieve maximum efficiency, parallel control of microlitre droplets using automated techniques is essential. Electrowetting-on-dielectric (EWOD), which manipulates droplets using the imbalance of wetting on a substrate, is the most widely employed method. However, EWOD is limited in its capability to make droplets detach from the substrate (jumping), which hinders throughput and device integration. Here, we propose a novel microfluidic system based on focused ultrasound passing through a hydrophobic mesh with droplets resting on top. A phased array dynamically creates foci to manipulate droplets of up to 300 μL. This platform offers a j

SUBMITTER: Koroyasu Y 

PROVIDER: S-EPMC10317206 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature