Association of reduced serum EGF and leptin levels with the pathophysiology of major depressive disorder: A case-control study

ABSTRACT:

Background

Major depressive disorder (MDD) is a heterogeneous mental disorder having a very diverse course and causing a significant changes in daily life. Though the exact pathophysiology of depression is still not known, an alteration in the serum levels of cytokines and neurotrophic factors was seen in MDD subjects. In this study, we compared the serum levels of ‘pro-inflammatory cytokine leptin and neurotrophic factor EGF’ in healthy controls (HCs) and MDD patients. To make the findings more accurate, we eventually looked for a correlation between altered serum leptin and EGF levels and the severity of the disease condition.

Methods

For this case-control study, about 205 MDD patients were enrolled from the Department of Psychiatry, Bangabandhu Sheikh Mujib Medical Uni

SUBMITTER: Sohan M 

PROVIDER: S-EPMC10317226 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature