The effect of age on the induction dose of propofol for general anesthesia in dogs.

ABSTRACT:

Objective

In people, the dose of propofol (DOP) required for procedural sedation and anesthesia decreases significantly with age. The objective of this study was to determine if the DOP required to perform endotracheal intubation decreases with age in dogs.

Study design

Retrospective case series.

Animals

1397 dogs.

Methods

Data from dogs anesthetized at referral center (2017-2020) were analyzed with three multivariate linear regression models with backward elimination using a combination of either absolute age, physiologic age, or life expectancy (ratio between age at the time of anesthetic event and expected age of death for each breed obtained from previous literature) as well as other factors as independent variables, and DOP as the dependent variable. The D

SUBMITTER: Hampton CE 

PROVIDER: S-EPMC10317228 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature