Gain modulation and odor concentration invariance in early olfactory networks.

ABSTRACT: The broad receptive field of the olfactory receptors constitutes the basis of a combinatorial code that allows animals to detect and discriminate many more odorants than the actual number of receptor types that they express. One drawback is that high odor concentrations recruit lower affinity receptors which can lead to the perception of qualitatively different odors. Here we addressed the contribution that signal-processing in the antennal lobe makes to reduce concentration dependence in odor representation. By means of calcium imaging and pharmacological approach we describe the contribution that GABA receptors play in terms of the amplitude and temporal profiles of the signals that convey odor information from the antennal lobes to higher brain centers. We found that GABA reduces the am

SUBMITTER: Marachlian E 

PROVIDER: S-EPMC10317235 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature