Biomarker-Based Risk Stratification in Pediatric Sepsis From a Low-Middle Income Country.

ABSTRACT:

Objectives

Most biomarker studies of sepsis originate from high-income countries, whereas mortality risk is higher in low- and middle-income countries. The second version of the Pediatric Sepsis Biomarker Risk Model (PERSEVERE-II) has been validated in multiple North American PICUs for prognosis. Given differences in epidemiology, we assessed the performance of PERSEVERE-II in septic children from Pakistan, a low-middle income country. Due to uncertainty regarding how well PERSEVERE-II would perform, we also assessed the utility of other select biomarkers reflecting endotheliopathy, coagulopathy, and lung injury.

Design

Prospective cohort study.

Setting

PICU in Aga Khan University Hospital in Karachi, Pakistan.

Patients

Children (< 18 yr old) meeting pediatric

SUBMITTER: Ishaque S 

PROVIDER: S-EPMC10317305 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature