Association of topiramate prescribed for any indication with reduced alcohol consumption in electronic health record data.

ABSTRACT:

Background and aims

Topiramate is a medication that is widely prescribed to treat a variety of conditions, including alcohol use disorder (AUD). We used electronic health record (EHR) data to measure topiramate's effects on drinking in individuals differentiated by a history of AUD.

Design

Parallel-groups comparison of patients prescribed topiramate and a propensity score-matched comparison group.

Setting

A large US integrated health-care system.

Participants

Patients with Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) scores prior to and after a minimum of 180 days of topiramate prescription for any indication and a propensity score-matched group. The sample included 5918 patients with an electronic health record diagnosis of alcohol use disor

SUBMITTER: Kranzler HR 

PROVIDER: S-EPMC10317468 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature