Utility of ctDNA in predicting relapse in solid tumors after curative therapy: a meta-analysis.

ABSTRACT:

Background

Presence of circulating tumor DNA (ctDNA) is prognostic in solid tumors treated with curative intent. Studies have evaluated ctDNA at specific "landmark" or multiple "surveillance" time points. However, variable results have led to uncertainty about its clinical validity.

Methods

A PubMed search identified relevant studies evaluating ctDNA monitoring in solid tumors after curative intent therapy. Odds ratios for recurrence at both landmark and surveillance time points for each study were calculated and pooled in a meta-analysis using the Peto method. Pooled sensitivity and specificity weighted by individual study inverse variance were estimated and meta-regression using linear regression weighted by inverse variance was performed to explore associations between pa

SUBMITTER: Mittal A 

PROVIDER: S-EPMC10317487 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature