Dirofilaria immitis possesses molecules with anticoagulant properties in its excretory/secretory antigens.

ABSTRACT: Dirofilaria immitis is a parasitic nematode that survives in the circulatory system of suitable hosts for many years, causing the most severe thromboembolisms when simultaneous death of adult worms occurs. The two main mechanisms responsible for thrombus formation in mammals are the activation and aggregation of platelets and the generation of fibrin through the coagulation cascade. The aim of this work was to study the anticoagulant potential of excretory/secretory antigens from D. immitis adult worms (DiES) on the coagulation cascade of the host. Anticoagulant and inhibition assays respectively showed that DiES partially alter the coagulation cascade of the host and reduce the activity of the coagulation factor Xa, a key enzyme in the coagulation process. In addition, a D. immitis protei

SUBMITTER: Diosdado A 

PROVIDER: S-EPMC10317642 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature