Computational approaches for drug discovery against trypanosomatid-caused diseases.

ABSTRACT: During three decades, only about 20 new drugs have been developed for malaria, tuberculosis and all neglected tropical diseases (NTDs). This critical situation was reached because NTDs represent only 10% of health research investments; however, they comprise about 90% of the global disease burden. Computational simulations applied in virtual screening (VS) strategies are very efficient tools to identify pharmacologically active compounds or new indications for drugs already administered for other diseases. One of the advantages of this approach is the low time-consuming and low-budget first stage, which filters for testing experimentally a group of candidate compounds with high chances of binding to the target and present trypanocidal activity. In this work, we review the most common VS st

SUBMITTER: Pereira CA 

PROVIDER: S-EPMC10317681 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature