Effective connectivity during face processing in major depression - distinguishing markers of pathology, risk, and resilience.

ABSTRACT:

Background

Aberrant brain connectivity during emotional processing, especially within the fronto-limbic pathway, is one of the hallmarks of major depressive disorder (MDD). However, the methodological heterogeneity of previous studies made it difficult to determine the functional and etiological implications of specific alterations in brain connectivity. We previously reported alterations in psychophysiological interaction measures during emotional face processing, distinguishing depressive pathology from at-risk/resilient and healthy states. Here, we extended these findings by effective connectivity analyses in the same sample to establish a refined neural model of emotion processing in depression.

Methods

Thirty-seven patients with MDD, 45 first-degree relatives of patient

SUBMITTER: Sacu S 

PROVIDER: S-EPMC10317809 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature