Brain morphometric features predict medication response in youth with bipolar disorder: a prospective randomized clinical trial.

ABSTRACT:

Background

Identification of treatment-specific predictors of drug therapies for bipolar disorder (BD) is important because only about half of individuals respond to any specific medication. However, medication response in pediatric BD is variable and not well predicted by clinical characteristics.

Methods

A total of 121 youth with early course BD (acute manic/mixed episode) were prospectively recruited and randomized to 6 weeks of double-blind treatment with quetiapine (n = 71) or lithium (n = 50). Participants completed structural magnetic resonance imaging (MRI) at baseline before treatment and 1 week after treatment initiation, and brain morphometric features were extracted for each individual based on MRI scans. Positive antimanic treatment response at wee

SUBMITTER: Lei D 

PROVIDER: S-EPMC10317810 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature