Antipsychotic polypharmacy and adverse drug reactions among adults in a London mental health service, 2008-2018.

ABSTRACT:

Background

Antipsychotic polypharmacy (APP) occurs commonly but it is unclear whether it is associated with an increased risk of adverse drug reactions (ADRs). Electronic health records (EHRs) offer an opportunity to examine APP using real-world data. In this study, we use EHR data to identify periods when patients were prescribed 2 + antipsychotics and compare these with periods of antipsychotic monotherapy. To determine the relationship between APP and subsequent instances of ADRs: QT interval prolongation, hyperprolactinaemia, and increased body weight [body mass index (BMI) ⩾ 25].

Methods

We extracted anonymised EHR data. Patients aged 16 + receiving antipsychotic medication at Camden & Islington NHS Foundation Trust between 1 January 2008 and 31 December 2018 were inclu

SUBMITTER: Yang JC 

PROVIDER: S-EPMC10317812 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature