Spatial single cell analysis of tumor microenvironment remodeling pattern in primary central nervous system lymphoma.

ABSTRACT: To determine the overall tumor microenvironment (TME), characteristics, and transition mechanisms in primary central nervous system lymphoma (PCNSL), we performed spatial transcriptomics and matched the corresponding single-cell sequencing data of PCNSL patients. We found that tumor cells may achieve a "TME remodeling pattern" through an "immune pressure-sensing model", in which they could choose to reshape the TME into a barrier environment or a cold environment according to the immune pressure. A key FKBP5⁺ tumor subgroup was found to be responsible for pushing tumors into the barrier environment, which provides a possible way to evaluate the stage of PCNSL. The specific mechanism of the TME remodeling pattern and the key molecules of the immune pressure-sensing model were ide

SUBMITTER: Xia Y 

PROVIDER: S-EPMC10317840 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature