Ischemic Heart Disease and Vascular Risk Factors Are Associated With Accelerated Brain Aging.

ABSTRACT:

Background

Ischemic heart disease (IHD) has been linked with poor brain outcomes. The brain magnetic resonance imaging-derived difference between predicted brain age and actual chronological age (brain-age delta in years, positive for accelerated brain aging) may serve as an effective means of communicating brain health to patients to promote healthier lifestyles.

Objectives

The authors investigated the impact of prevalent IHD on brain aging, potential underlying mechanisms, and its relationship with dementia risk, vascular risk factors, cardiovascular structure, and function.

Methods

Brain age was estimated in subjects with prevalent IHD (n = 1,341) using a Bayesian ridge regression model with 25 structural (volumetric) brain magnetic resonance imaging features and b

SUBMITTER: Rauseo E 

PROVIDER: S-EPMC10317841 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature