Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets.

ABSTRACT:

Aims/hypothesis

After birth, the neonatal islets gradually acquire glucose-responsive insulin secretion, a process that is subjected to maternal imprinting. Although NEFA are major components of breastmilk and insulin secretagogues, their role for functional maturation of neonatal beta cells is still unclear. NEFA are the endogenous ligands of fatty acid receptor 1 (FFA1, encoded by Ffar1 in mice), a Gq-coupled receptor with stimulatory effect on insulin secretion. This study investigates the role of FFA1 in neonatal beta cell function and in the adaptation of offspring beta cells to parental high-fat feeding.

Methods

Wild-type (WT) and Ffar1^-/- mice were fed high-fat (HFD) or chow diet (CD) for 8 weeks before mating, and during gestation and lactation. Blood vari

SUBMITTER: Lorza-Gil E 

PROVIDER: S-EPMC10317898 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature