Predictive value of ^99mTc-MAA-based dosimetry in personalized ⁹⁰Y-SIRT planning for liver malignancies.

ABSTRACT:

Background

Selective internal radiation therapy with ⁹⁰Y radioembolization aims to selectively irradiate liver tumours by administering radioactive microspheres under the theragnostic assumption that the pre-therapy injection of ^99mTc labelled macroaggregated albumin (^99mTc-MAA) provides an estimation of the ⁹⁰Y microspheres biodistribution, which is not always the case. Due to the growing interest in theragnostic dosimetry for personalized radionuclide therapy, a robust relationship between the delivered and pre-treatment radiation absorbed doses is required. In this work, we aim to investigate the predictive value of absorbed dose metrics calculated from ^99mTc-MAA (simulation) compared to those obtained from ⁹⁰Y po

SUBMITTER: Riveira-Martin M 

PROVIDER: S-EPMC10317941 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature