Higher CD4⁺CD40⁺ T cells (Th40 cells) associate with systemic lupus erythematosus activity.

ABSTRACT: The aim of this study was to investigate the characteristics of CD4⁺CD40⁺ T cells (Th40 cells) in Chinese systemic lupus erythematosus (SLE) patients. Flow cytometry was used to identify the percentage of Th40 cells in peripheral blood from 24 SLE patients and 24 healthy individuals and the level of IL-2, IL-4, IL-6, IL-10, IFN-r, and TNF-α in serum (22 cases) from the SLE patients. Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2000) was used to assess the SLE disease active state. The percentage of Th40 cells in T cells from SLE patients (19.37 ± 17.43) (%) was significantly higher than that from healthy individuals (4.52 ± 3.16) (%) (P < 0.001). The percentage of Th40 cells was also positively associated with SLEDAI-2000 (P = 0.001) and negatively

SUBMITTER: Zhu L 

PROVIDER: S-EPMC10317960 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature