Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders.

ABSTRACT: Irritability is a heritable core mental trait associated with several psychiatric illnesses. However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify the genetic variants associated with irritability and investigate the associated biological pathways, genes, and tissues as well as single-nucleotide polymorphism (SNP)-based heritability; 2) explore the relationships between irritability and various traits, including psychiatric disorders; and 3) identify additional and shared genetic variants for irritability and psychiatric disorders. We conducted a genome-wide association study (GWAS) using 379,506 European samples (105,975 cases and 273,531 controls) from the UK Biobank. We utilized various post-GWAS analyses, including linkage disequilibrium scor

SUBMITTER: Jung K 

PROVIDER: S-EPMC10317967 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature