Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications.

ABSTRACT: Sarcomas constitute a heterogeneous group of rare and difficult-to-treat tumors that can affect people of all ages, representing one of the most common forms of cancer in childhood and adolescence. Little is known about the molecular entities involved in sarcomagenesis. Therefore, the identification of processes that lead to the development of the disease may uncover novel therapeutic opportunities. Here, we show that the MEK5/ERK5 signaling pathway plays a critical role in the pathogenesis of sarcomas. By developing a mouse model engineered to express a constitutively active form of MEK5, we demonstrate that the exclusive activation of the MEK5/ERK5 pathway can promote sarcomagenesis. Histopathological analyses identified these tumors as undifferentiated pleomorphic sarcomas. Bioinformati

SUBMITTER: Sanchez-Fdez A 

PROVIDER: S-EPMC10317974 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature