The genomic and transcriptomic landscape of advanced renal cell cancer for individualized treatment strategies.

ABSTRACT: Differences in the clinical course and treatment responses in individual patients with advanced renal cell carcinoma (RCC) can largely be explained by the different genomics of this disease. To improve the personalized treatment strategy and survival outcomes for patients with advanced RCC, the genomic make-up in patients with advanced RCC was investigated to identify putative actionable variants and signatures. In this prospective multicenter study (NCT01855477), whole-genome sequencing (WGS) data of locally advanced and metastatic tissue biopsies and matched whole-blood samples were collected from 91 patients with histopathologically confirmed RCC. WGS data were analyzed for small somatic variants, copy-number alterations and structural variants. For a subgroup of patients, RNA sequencin

SUBMITTER: de Joode K 

PROVIDER: S-EPMC10318030 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature