Ventromedial prefrontal neurons represent self-states shaped by vicarious fear in male mice.

ABSTRACT: Perception of fear induced by others in danger elicits complex vicarious fear responses and behavioral outputs. In rodents, observing a conspecific receive aversive stimuli leads to escape and freezing behavior. It remains unclear how these behavioral self-states in response to others in fear are neurophysiologically represented. Here, we assess such representations in the ventromedial prefrontal cortex (vmPFC), an essential site for empathy, in an observational fear (OF) paradigm in male mice. We classify the observer mouse's stereotypic behaviors during OF using a machine-learning approach. Optogenetic inhibition of the vmPFC specifically disrupts OF-induced escape behavior. In vivo Ca²⁺ imaging reveals that vmPFC neural populations represent intermingled information of other-

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10318047 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature