Is it all in the baseline? Trajectories of chair stand performance over 4 years and their association with grey matter structure in older adults.

ABSTRACT: Understanding individual variability in response to physical activity is key to developing more effective and personalised interventions for healthy ageing. Here, we aimed to unpack individual differences by using longitudinal data from a randomised-controlled trial of a 12-month muscle strengthening intervention in older adults. Physical function of the lower extremities was collected from 247 participants (66.3 ± 2.5 years) at four time-points. At baseline and at year 4, participants underwent 3 T MRI brain scans. K-means longitudinal clustering was used to identify patterns of change in chair stand performance over 4 years, and voxel-based morphometry was applied to map structural grey matter volume at baseline and year 4. Results identified three groups showing trajectories of poor (33

SUBMITTER: Demnitz N 

PROVIDER: S-EPMC10318211 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature