Cardiovascular Substructure Dose and Cardiac Events following Proton- and Photon-Based Chemoradiotherapy for Non-Small Cell Lung Cancer

ABSTRACT:

Purpose

Radiation therapy (RT) plays a critical role in treating locally advanced non-small cell lung cancer but has been associated with deleterious cardiac effects. We hypothesized that RT dose to certain cardiovascular substructures may be higher among those who experience post-chemoradiation (CRT) cardiac events, and that dose to specific substructures—the great vessels, atria, ventricles, and left anterior descending coronary artery—may be lower with proton- versus photon-based RT.

Methods and Materials

In this retrospective review, we selected 26 patients who experienced cardiac events after CRT for locally advanced non-small cell lung cancer and matched them to 26 patients who did not experience cardiac events after CRT. Matching was done based on RT technique (pro

SUBMITTER: Natarajan J 

PROVIDER: S-EPMC10318212 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature