Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.

ABSTRACT: There is a pressing need to understand the factors that predict prognosis in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), with high heterogeneity over the poor average survival. We test the hypothesis that the magnitude and distribution of connectivity changes in PSP and CBS predict the rate of progression and survival time, using datasets from the Cambridge Centre for Parkinson-plus and the UK National PSP Research Network (PROSPECT-MR). Resting-state functional MRI images were available from 146 participants with PSP, 82 participants with CBS, and 90 healthy controls. Large-scale networks were identified through independent component analyses, with correlations taken between component time series. Independent component analysis was also used to select between-net

SUBMITTER: Whiteside DJ 

PROVIDER: S-EPMC10318264 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature