VEGF-B hypertrophy predisposes to transition from diastolic to systolic heart failure in hypertensive rats.

ABSTRACT:

Aims

Cardiac energy metabolism is centrally involved in heart failure (HF), although the direction of the metabolic alterations is complex and likely dependent on the particular stage of HF progression. Vascular endothelial growth factor B (VEGF-B) has been shown to modulate metabolic processes and to induce physiological cardiac hypertrophy; thus, it could be cardioprotective in the failing myocardium. This study investigates the role of VEGF-B in cardiac proteomic and metabolic adaptation in HF during aldosterone and high-salt hypertensive challenges.

Methods and results

Male rats overexpressing the cardiac-specific VEGF-B transgene (VEGF-B TG) were treated for 3 or 6 weeks with deoxycorticosterone-acetate combined with a high-salt (HS) diet (DOCA + HS) to induce hypertens

SUBMITTER: Samuelsson AM 

PROVIDER: S-EPMC10318391 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature