The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.

ABSTRACT:

Aims

The ageing heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt. However, some exceptional individuals maintain good health until the very late stage of their life due to favourable gene-environment interaction. We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health spans and lesser cardiovascular complications. Moreover, supplementation of LAV-BPIFB4 via an adeno-associated viral vector improves cardiovascular performance in limb ischaemia, atherosclerosis, and diabetes models. Here, we asked whether the LAV-BPIFB4 gene could address the unmet therapeutic need to delay the heart's spontaneous ageing.

Methods and results

Immunohistological studies sh

SUBMITTER: Cattaneo M 

PROVIDER: S-EPMC10318395 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature