Luteolin reduces cardiac damage caused by hyperlipidemia in Sprague-Dawley rats

ABSTRACT:

Objective

Hyperlipidemia is a risk factor for cardiac damage that can lead to many cardiovascular diseases. A recent study reported the cardioprotective effects of luteolin in vitro and in vivo. In this study, we aimed to investigate the possible protective effects of luteolin against hyperlipidemia-induced cardiac damage in Sprague-Dawley (SD) rats.

Methods

Six-week-old male SD rats were randomly divided into five groups: a normal diet (ND) group; a high-fat diet (HFD) group; and three high-fat diet mixed with luteolin (HFD + LUT) groups, where in a luteolin dosage 50, 100, or 200 mg/kg/day was administered. All groups were fed their respective diets for 12 weeks.

Results

Left ventricular ejection fraction and fractional shortening (parameters of cardiac functio

SUBMITTER: Dong M 

PROVIDER: S-EPMC10318514 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature