Utilization of dietary mixed-linkage β-glucans by the Firmicute Blautia producta.

ABSTRACT: The β-glucans are structurally varied, naturally occurring components of the cell walls, and storage materials of a variety of plant and microbial species. In the human diet, mixed-linkage glucans [MLG - β-(1,3/4)-glucans] influence the gut microbiome and the host immune system. Although consumed daily, the molecular mechanism by which human gut Gram-positive bacteria utilize MLG largely remains unknown. In this study, we used Blautia producta ATCC 27340 as a model organism to develop an understanding of MLG utilization. B. producta encodes a gene locus comprising a multi-modular cell-anchored endo-glucanase (BpGH16_MLG), an ABC transporter, and a glycoside phosphorylase (BpGH94_MLG) for utilizing MLG, as evidenced by the upregulation of expression of the enzyme- and so

SUBMITTER: Singh RP 

PROVIDER: S-EPMC10318527 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature