Identification and classification of papain-like cysteine proteinases.

ABSTRACT: Papain-like cysteine peptidases form a big and highly diverse superfamily of proteins involved in many important biological functions, such as protein turnover, deubiquitination, tissue remodeling, blood clotting, virulence, defense, and cell wall remodeling. High sequence and structure diversity observed within these proteins hinders their comprehensive classification as well as the identification of new representatives. Moreover, in general protein databases, many families already classified as papain like lack details regarding their mechanism of action or biological function. Here, we use transitive remote homology searches and 3D modeling to newly classify 21 families to the papain-like cysteine peptidase superfamily. We attempt to predict their biological function and provide structu

SUBMITTER: Ozhelvaci F 

PROVIDER: S-EPMC10318531 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature