Inflammation biomarkers IL‐6 and IL‐10 may improve the diagnostic and prognostic accuracy of currently authorized traumatic brain injury tools

ABSTRACT: Traumatic brain injury (TBI) is currently one of the leading causes of mortality and disability worldwide. At present, no reliable inflammatory or specific molecular neurobiomarker exists in any of the standard models proposed for TBI classification or prognostication. Therefore, the present study was designed to assess the value of a group of inflammatory mediators for evaluating acute TBI, in combination with clinical, laboratory and radiological indices and prognostic clinical scales. In the present single-centre, prospective observational study, 109 adult patients with TBI, 20 adult healthy controls and a pilot group of 17 paediatric patients with TBI from a Neurosurgical Department and two intensive care units of University General Hospital of Heraklion, Greece were recruited. Blood m

SUBMITTER: Tsitsipanis C 

PROVIDER: S-EPMC10318605 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature