Parabens Promote Protumorigenic Effects in Luminal Breast Cancer Cell Lines With Diverse Genetic Ancestry.

ABSTRACT:

Context

One in 8 women will develop breast cancer in their lifetime. Yet, the burden of disease is greater in Black women. Black women have a 40% higher mortality rate than White women, and a higher incidence of breast cancer at age 40 and younger. While the underlying cause of this disparity is multifactorial, exposure to endocrine disrupting chemicals (EDCs) in hair and other personal care products has been associated with an increased risk of breast cancer. Parabens are known EDCs that are commonly used as preservatives in hair and other personal care products, and Black women are disproportionately exposed to products containing parabens.

Objective

Studies have shown that parabens impact breast cancer cell proliferation, death, migration/invasion, and metabolism, as well

SUBMITTER: Tapia JL 

PROVIDER: S-EPMC10318621 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature