Eligibility criteria in clinical trials in breast cancer: a cohort study.

ABSTRACT:

Background

Breast cancer (BC) is the most common cancer type in women. The purpose of this study was to assess the eligibility criteria in recent clinical trials in BC, especially those that can limit the enrollment of older patients as well as those with comorbidities and poor performance status.

Methods

Data on clinical trials in BC were extracted from ClinicalTrials.gov. Co-primary outcomes were proportions of trials with different types of the eligibility criteria. Associations between trial characteristics and the presence of certain types of these criteria (binary variable) were determined with univariate and multivariate logistic regression.

Results

Our analysis included 522 trials of systemic anticancer treatments started between 2020 and 2022. Upper age limit

SUBMITTER: Szlezinger K 

PROVIDER: S-EPMC10318672 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature