Progressive trajectories of schizophrenia across symptoms, genes, and the brain.

ABSTRACT:

Background

Schizophrenia is characterized by complex psychiatric symptoms and unclear pathological mechanisms. Most previous studies have focused on the morphological changes that occur over the development of the disease; however, the corresponding functional trajectories remain unclear. In the present study, we aimed to explore the progressive trajectories of patterns of dysfunction after diagnosis.

Methods

Eighty-six patients with schizophrenia and 120 healthy controls were recruited as the discovery dataset. Based on multiple functional indicators of resting-state brain functional magnetic resonance imaging, we conducted a duration-sliding dynamic analysis framework to investigate trajectories in association with disease progression. Neuroimaging findings were associated

SUBMITTER: Jiang S 

PROVIDER: S-EPMC10318676 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature