Pharmacological inhibition of demethylzeylasteral on JAK-STAT signaling ameliorates vitiligo.

ABSTRACT:

Background

The activation of CD8⁺ T cells and their trafficking to the skin through JAK-STAT signaling play a central role in the development of vitiligo. Thus, targeting this key disease pathway with innovative drugs is an effective strategy for treating vitiligo. Natural products isolated from medicinal herbs are a useful source of novel therapeutics. Demethylzeylasteral (T-96), extracted from Tripterygium wilfordii Hook F, possesses immunosuppressive and anti-inflammatory properties.

Methods

The efficacy of T-96 was tested in our mouse model of vitiligo, and the numbers of CD8⁺ T cells infiltration and melanocytes remaining in the epidermis were quantified using whole-mount tail staining. Immune regulation of T-96 in CD8⁺ T cells was evalu

SUBMITTER: Chang Y 

PROVIDER: S-EPMC10318684 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature