Association between night shift work and NAFLD: a prospective analysis of 281,280 UK Biobank participants.

ABSTRACT:

Context

This study aimed to investigate the association between night shift work and the risk of nonalcoholic fatty liver disease (NAFLD).

Methods

We conducted a prospective analysis of 281,280 UK Biobank participants. Cox proportional hazards models were used to estimate the association of night shift work with incident NAFLD. Polygenic risk score analyses were performed to assess whether a genetic predisposition to NAFLD modified the association.

Results

During a median follow-up of 12.1 years (3,373,964 person-years), 2,555 incident NAFLD cases were identified. Compared with workers who never/rarely worked night shifts, those who worked some night shifts or usual/permanent night shifts were 1.12 (95% CI: 0.96-1.31) and 1.27 (95% CI: 1.08-1.48) times more likely to

SUBMITTER: Huang H 

PROVIDER: S-EPMC10318710 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature