Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function.

ABSTRACT:

Background

Inflammation is a fundamental biological response to injury and infection, which if unregulated can contribute to the pathophysiology of many diseases. The vagus nerve, which primarily originates from the dorsal motor nucleus (DMN), plays an important role in rapidly dampening inflammation by regulating splenic function. However, direct vagal innervation of the spleen, which houses the majority of immune and inflammatory cells, has not been established. As an alternative to direct innervation, an anti-inflammatory reflex pathway has been proposed which involves the vagus nerve, the sympathetic celiac ganglion, and the neurotransmitter norepinephrine. Although sympathetic regulation of inflammation has been shown, the interaction of the vagus nerve and the celiac ganglia

SUBMITTER: Kobori N 

PROVIDER: S-EPMC10318820 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature